A Dual‐Function Micro‐Swiss‐Roll Device: High‐Power Supercapacitor and Biomolecule Probe

Sesterin as a biomolecule

Sestrins (Sesns), highly conserved stress-inducing metabolic proteins, are known to protect organisms against various harmful stimuli including DNA damage, oxidative stress, endoplasmic reticulum (ER) stress, and hypoxia. Sestrins regulate metabolism mainly through activation of AMP-dependent protein kinase (AMPK) and inhibition of rapamycin complex 1 (mTORC1). Sestrins also play a pivotal role...

Reversible Energy Storage on a Fuel Cell-supercapacitor Hybrid Device

Membrane device for holding biomolecule samples for terahertz spectroscopy

A device for holding biomolecule samples on a membrane allows scanning using terahertz frequency waves. Such scanning has previously been difficult due to the strong attenuation of terahertz frequency waves by water. Several types of biomolecules were scanned using terahertz time domain spectroscopy (TDS), and the data showed clear differences in transmittance among the samples. This membrane d...

Photodynamic therapy by a device probe tip

A pointsource photodynamic therapy (PDT) technique has been developed to deliver sensitizer, light and oxygen that are precursors to singlet oxygen (a cytotoxic excited state of O2) in a highly localized and controllable fashion. The characterization of cell killing radius in vitro provides insight into the release kinetics and diffusion of the sensitizer. This opens the door to an instrument t...

Templated xerogels as platforms for biomolecule-less biomolecule sensors.

We report on a new sensor strategy that we have termed protein imprinted xerogels with integrated emission sites (PIXIES). The PIXIES platform is completely self-contained, and it achieves analyte recognition without a biorecognition element (e.g., antibody). The PIXIES relies upon sol-gel-derived xerogels, molecular imprinting, and the selective installation of a luminescent reporter molecule ...